No one should take more than 300 mcg per day of chromium without the supervision of a doctor. 15 Whether these problems were caused by chromium picolinate or, if so, whether other forms of chromium might have the same effects at these high amounts remains unclear. 14 A case of a muscle disease known as rhabdomyolysis appeared in a body builder who took 1200 mcg over 48 hours. 13 A case of anemia, liver dysfunction, and other problems appeared after four to five months of 1,200–2,400 mcg per day. A case of kidney failure appeared after taking 600 mcg per day for six weeks. However, most trials using chromium picolinate supplements, with or without exercise, found no significant benefit for weight loss or percent body fat reduction. 9 Chromium picolinate is widely marketed to the public with diverse health claims pertaining to glucose metabolism, insulin action, muscle mass, weight control, and diabetes prevention. Some chromium studies have shown these benefits. The micronutrient chromium (Cr) is of interest in this regard as a potential means of improving glucose tolerance 7, 8 by reducing insulin resistance. Some chromium studies have shown these benefits, but others have not. Three single, unrelated cases of toxicity have been reported from use of chromium picolinate. Some people use chromium supplements to build muscle or trigger weight loss. 12 However, no published evidence supports this assertion. It can be taken in supplemental form to lower cholesterol levels, control symptoms of type two diabetes, and promote weight loss. Another source claimed that there have been reports of mild heart rhythm abnormalities with excessive chromium ingestion. Chromium is a trace element that plays an important role in regulating your body’s metabolism and blood chemistry. 11 However, chromium supplementation was not proven to be the cause of these problems. Weight and lean body mass Some chromium supplements are marketed for weight loss and to reduce body fat and increase muscle mass. One report of severe illness (including liver and kidney damage) occurring in a person who was taking 1,000 mcg of chromium per day has been reported. 9 In theory, these changes could increase the risk of cancer, but so far, chromium intake has not been linked to increased incidence of cancer in humans. 7, 8 Chromium picolinate can be altered by antioxidants or hydrogen peroxide in the body to a form that could itself create free radical damage. One study suggested that chromium in very high concentrations in a test tube could cause chromosomal mutations in ovarian cells of hamsters. After days of researching and comparing all models on the market 2021, JohnHarvards find Best Chromium Polynicotinate Weight Loss Reviews of June 2023. While there are a few reports of people developing medical problems while taking chromium, a cause-effect relationship was not proven. In supplemental amounts (typically 50–300 mcg per day), chromium has not been found to cause toxicity in humans.
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